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Leaky Gut Test | Lactulose/Mannitol (Most Popular)
Leaky Gut Test | Lactulose/Mannitol (Most Popular)
Draw Locations For This Test How We Work FAQs
Prescriptive authority by Jeffery Donohue, MD.
Regular Price: $286.00
Your Price: $199.00


Lab Test Description

Leaky Gut Test (Intestinal Permeability Test) | Home Test
Lactulose and Mannitol Test

The Leaky Gut Test (or Intestinal Permeability Test) is a noninvasive gastrointestinal test that measures small intestinal absorption and barrier function in the bowel. Malabsorption and increased intestinal permeability (leaky gut) can be associated with chronic gastrointestinal imbalances.

How Does the Leaky Gut Test Work?

The Leaky Gut Test requires you to complete a baseline morning urine sample. Afterwards, you will be required to drink a mixture of two non-metabolized sugars, lactulose, and mannitol. After six hours, you will collect an additional sample of urine. The lab will measure how much lactulose and mannitol was excreted.

If Leaky Gut Syndrome is NOT present, the large lactulose molecules should remain in the GI tract and thus test low in the urine. If the count is high in the urine, Leaky Gut Syndrome should be considered.

Possible Causes of Leaky Gut:

  • Intestinal infection (test panel)
  • Ingestion of allergenic foods (test panel)
  • Trauma
  • Toxic chemicals (test panels)
  • NSAIDs such as aspirin, ibuprofen, naproxen etc.

How Can The Leaky Gut Test Help?

The Leaky Gut Test is extremely important when beginning restorative treatment plans. As intestinal health improves, the lactulose/mannitol ratio should improve.

Since ongoing monitoring is recommended by most doctors, we extend a 10% discount when you order 2 or more leaky gut tests at the same time (automatically discounted at checkout).

What's Being Tested in this Panel?

  • Creatine
  • Lactulose
  • Mannitol
  • Total Urine Volume
  • Includes: Mannitol/Lactulose Drink

To prevent an incorrect mannitol reading, please avoid the following foods 48 hours before collection:

  • Strawberries
  • Celery
  • Onions
  • Pumpkin
  • Mushrooms
  • Jams/Jelly
  • Cough Drops
  • Hard and Soft Candies
  • Lactobacillus Probiotic Supplementation
Sample Report

Collection instructions and other details

Specimen Type: Urine, Genova Home Test Kit (How It Works | FAQs)

Turnaround Time: 7 days


  • Disclaimer: By ordering this test, you agree that you have first consulted with your treating physician and have been learned for the use of lactulose and mannitol. Do not conduct this test if you are allergic to lactulose, mannitol, galactose, or are on a galactose/lactose/mannitol restricted diet. Do not conduct this test if you are diabetic. Do not conduct this test if you have kidney dysfunction. This test is ordered by Jeffery Donohue, MD with prescriptive authority.
  • This kit can be ordered only within the US states including New York State.
  • Certain medications such as aspirin, other anti-inflammatory drugs, antacids containing aluminum or magnesium hydroxide (eg, Maalox liquid, Equate, Milk of Magnesia, Rolaids, Mylanta) as well as drugs that contain sorbitol and/or mannitol may affect your test results. Please consult with your healthcare professional know about any medications or supplements you are using before taking this test. It is recommended that you avoid the use of these medicines for at least 72 hours before taking this test.

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