Tissue Transglutaminase IgA and IgG Antibodies Test
The Tissue Transglutaminase (tTG) IgA and IgG Antibodies Test is a blood test used to diagnose celiac disease. This test checks for the presence of specific antibodies (proteins produced by the immune system) that indicate an immune reaction to gluten.
Why is this test important in medicine and functional medicine?
This test plays a crucial role in diagnosing celiac disease and dermatitis herpetiformis, especially in patients who present with atypical symptoms or are at increased risk due to family history. In functional medicine, it helps in understanding the underlying causes of gluten sensitivity and guides dietary and lifestyle interventions.
| Antibody Type | Reference Range | Status |
|---|---|---|
| tTG Antibody, IgA | <4.0 U/mL | Negative |
| tTG Antibody, IgA | 4.0-10.0 U/mL | Weak Positive |
| tTG Antibody, IgA | >10.0 U/mL | Positive |
| tTG Antibody, IgG | <6.0 U/mL | Negative |
| tTG Antibody, IgG | 6.0-9.0 U/mL | Weak Positive |
| tTG Antibody, IgG | >9.0 U/mL | Positive |
Why should someone order this test?
Ordering this test is vital for individuals experiencing symptoms of celiac disease or those with a family history of the condition. It’s also recommended for individuals with related autoimmune disorders or those who have tested positive for HLA DQ2 and/or DQ8 genes, associated with celiac disease.
What’s Being Tested:
- Tissue Transglutaminase (tTG) IgA +IgG
Frequently Asked Questions (FAQ)
- What does the Tissue Transglutaminase IgA and IgG Antibodies Test detect?
This test detects antibodies specific to celiac disease, indicating an immune response to gluten. - Who should consider taking this test?
Individuals with symptoms of celiac disease, a family history of the condition, or associated autoimmune disorders should consider this test. - How is this test different from other celiac disease tests?
The tTG IgA test is particularly useful in diagnosing celiac disease, especially in IgA-deficient patients. The tTG IgG test provides additional support for gluten sensitivity beyond the IgA test. - Can this test diagnose celiac disease on its own?
While positive results are indicative of celiac disease, a small intestinal biopsy is often recommended to confirm the diagnosis. - Is it necessary to be on a gluten-containing diet for this test to be accurate?
Yes, for the most accurate results, it is recommended to be on a gluten-containing diet before taking the test.
Find Out More:
To learn more about this test, visit our comprehensive Tissue Transglutaminase IgA and IgG Antibodies Test guide.
References
WebMD: Tissue Transglutaminase IgA Test
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Labs team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
